Screening of medicinal plants from Suriname for 5-HT1A ligands: Bioactive isoquinoline alkaloids from the fruit of Annona muricata
JA Hasrat, L Pieters, JP De Backer, G Vauquelin… - Phytomedicine, 1997 - Elsevier
Plants from Suriname (South-America) and several Annona species, including A. muricata,
A. ckerimolia, A. montana and A. glabra were screened for 5-HT1A receptor binding activity
by ligand-binding-studies (LBS). Crude extracts of all Annona species and from Hibiscus
bifurcatus, Irlbarchia purpurascens and Scoparia dulcis showed high activity. The
isoquinoline alkaloids asimilobine (1), nornuciferine (2), and annonaine (3) were isolated as
the active principles from the fruit of Annona muricata. These results may partially explain …
A. ckerimolia, A. montana and A. glabra were screened for 5-HT1A receptor binding activity
by ligand-binding-studies (LBS). Crude extracts of all Annona species and from Hibiscus
bifurcatus, Irlbarchia purpurascens and Scoparia dulcis showed high activity. The
isoquinoline alkaloids asimilobine (1), nornuciferine (2), and annonaine (3) were isolated as
the active principles from the fruit of Annona muricata. These results may partially explain …
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